Breed-specific lipid-related gene expression in the subcutaneous fat of Large White and Erhualian pigs at weaning

Zheng, Y.; Pan, S.; Huang, Y.; Ci, L.; Zhao, R.; Yang, X.

doi:https://doi.org/10.5194/aab-58-33-2015

Articles | Volume 58, issue 1

Article
Metrics
Related articles

Articles | Volume 58, issue 1

https://doi.org/10.5194/aab-58-33-2015

Articles | Volume 58, issue 1

Article
Metrics
Related articles

04 Mar 2015

| 04 Mar 2015

Breed-specific lipid-related gene expression in the subcutaneous fat of Large White and Erhualian pigs at weaning

Y. Zheng, S. Pan, Y. Huang, L. Ci, R. Zhao, and X. Yang

Y. Zheng

Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural University, Nanjing, China

S. Pan

Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural University, Nanjing, China

Y. Huang

Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural University, Nanjing, China

L. Ci

Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural University, Nanjing, China

R. Zhao

Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural University, Nanjing, China

X. Yang

CORRESPONDING AUTHOR

yangxj@njau.edu.cn

Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural University, Nanjing, China

Cited articles

Bao, Y., Bing, C., Hunter, L., Jenkins, J. R., Wabitsch, M., and Trayhurn, P.: Zinc-α2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes, FEBS Lett., 579, 41–47, 2005.

Bing, C., Bao, Y., Jenkins, J., Sanders, P., Manieri, M., Cinti, S., Tisdale, M. J., and Trayhurn, P.: Zinc-α2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia, P. Natl. Acad. Sci. USA, 101, 2500–2505, 2004.

Ceperuelo-Mallafré, V., Näf, S., Escoté, X., Caubet, E., Gomez, J. M., Miranda, M., Chacon, M. R., Gonzalez-Clemente, J. M., Gallart, L., Gutierrez, C., and Vendrell, J.: Circulating and Adipose Tissue Gene Expression of Zinc-α2-Glycoprotein in Obesity: Its Relationship with Adipokine and Lipolytic Gene Markers in Subcutaneous and Visceral Fat, J. Clin. Endocrinol. Metab., 94, 5062–5069, 2009.

Dahlman, I., Kaaman, M., Olsson, T., Tan, G. D., Bickerton, A. S. T., Wåhlén, K., Andersson, J., Nordström, E. A., Blomqvist, L., Sjögren, A., Forsgren, M., Attersand, A., and Arner, P.: A Unique Role of Monocyte Chemoattractant Protein 1 among Chemokines in Adipose Tissue of Obese Subjects, J. Clin. Endocrinol. Metab., 90, 5834–5840, 2005.

Darlington, G. J., Ross, S. E., and MacDougald, O. A.: The role of C/EBP genes in adipocyte differentiation, J. Biol. Chem., 273, 30057–30060, 1998.

Demars, J., Riquet, J., Sanchez, M. P., Billon, Y., Hocquette, J. F., Lebret, B., Iannuccelli, N., Bidanel, J. P., Milan, D., and Gondret, F.: Metabolic and histochemical characteristics of fat and muscle tissues in homozygous or heterozygous pigs for the body composition QTL located on chromosome 7, Physiol. Genomics, 30, 232–241, 2007.

Devine, J. H., Eubank, D. W., Clouthier, D. E., Tontonoz, P., Spiegelman, B. M., Hammer, R. E., and Beale, E. G.: Adipose Expression of the Phosphoenolpyruvate Carboxykinase Promoter Requires Peroxisome Proliferator-activated Receptor γ and 9-cis-Retinoic Acid Receptor Binding to an Adipocyte-specific Enhancer in Vivo, J. Biol. Chem., 274, 13604–13612, 1999.

Fantuzzi, G.: Adipose tissue, adipokines, and inflammation, J. Allergy Clin. Immunol., 115, 911–919, 2005.

Gao, D., Trayhurn, P., and Bing, C.: Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytes, Mol. Cell Endocrinol., 325, 135–142, 2010.

Gerfault, V., Louveau, I., and Mourot, J.: The Effect of GH and IGF-I on Preadipocytes from Large White and Meishan Pigs in Primary Culture, Gen. Comp. Endocr., 114, 396–404, 1999.

Gondret, F., Riquet, J., Tacher, S., Demars, J., Sanchez, M. P., Billon, Y., Robic, A., Bidanel, J. P., and Milan, D.: Towards candidate genes affecting body fatness at the SSC7 QTL by expression analyses, J. Anim. Breed Genet., 129, 316–324, 2012.

Gong, F. Y., Zhang, S. J., Deng, J. Y., Zhu, H. J., Pan, H., Li, N. S., and Shi, Y. F.: Zinc-α2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue, Int. J. Obes., 33, 1023–1030, 2009.

Granneman, J. G., Moore, H. P. H., Granneman, R. L., Greenberg, A. S., Obin, M. S., and Zhu, Z.: Analysis of Lipolytic Protein Trafficking and Interactions in Adipocytes, J. Biol. Chem., 282, 5726–5735, 2007.

Gregoire, F. M., Smas, C. M., and Sul, H. S.: Understanding Adipocyte Differentiation, Physiol. Rev., 78, 783–809, 1998.

Guerre-Millo, M.: Adipose tissue and adipokines: for better or worse, Diabetes Metab., 30, 13–19, 2004.

Koh, Y. J., Park, B. H., Park, J. H., Han, J., Lee, I. K., Park, J. W., and Koh, G. Y.: Activation of PPARγ induces profound multilocularization of adipocytes in adult mouse white adipose tissues, Exp. Mol. Med., 41, 880–895, 2009.

Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., Sugiyama, T., Eto, K., Tsubamoto, Y., Okuno, A., Murakami, K., Sekihara, H., Hasegawa, G., Naito, M., Toyoshima, Y., Tanaka, S., Shiota, K., Kitamura, T., Fujita, T., Ezaki, O., Aizawa, S., Nagai, R., Tobe, K., Kimura, S., and Kadowaki, T.: PPARγ Mediates High-Fat Diet-Induced Adipocyte Hypertrophy and Insulin Resistance, Mol. Cell, 4, 597–609, 1994.

Li, M., Li, X., Zhu, L., Jiang, Y., and Tang, G.: [Developmental expression changes of specific genes in adipose tissue for different pig breeds by using pathway-focused microarray], Chinese J. Biotech., 24, 665–672, 2008a (in Chinese).

Li, M., Zhu, L., Li, X., Shuai, S., Teng, X., Xiao, H., Li, Q., Chen, L., Guo, Y., and Wang, J.: Expression profiling analysis for genes related to meat quality and carcass traits during postnatal development of backfat in two pig breeds, Sci. China Ser. C, 51, 718–733, 2008b.

Li, Y., Li, H., Zhao, X., Li, N., and Wu, C.: UCP2 and 3 Deletion Screening and Distribution in 15 Pig Breeds, Biochem. Genet., 45, 103–111, 2007.

Mourot, J., Kouba, M., and Bonneau, M.: Comparative study of in vitro lipogenesis in various adipose tissue in the growing meishan pig: Comparison with the large white pig (Sus domesticus), Comp. Biochem. Phys. B, 115, 383–388, 1996.

Mracek, T., Ding, Q., Tzanavari, T., Kos, K., Pinkney, J., Wilding, J., Trayhurn, P., and Bing, C.: The adipokine zinc-α2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity, Clin. Endocrinol., 72, 334–341, 2010.

Nakajima, I., Oe, M., Ojima, K., Muroya, S., Shibata, M., and Chikuni, K.: Cellularity of developing subcutaneous adipose tissue in Landrace and Meishan pigs: Adipocyte size differences between two breeds, Anim. Sci. J., 82, 144–149, 2011.

Prusty, D., Park, B. H., Davis, K. E., and Farmer, S. R.: Activation of MEK/ERK Signaling Promotes Adipogenesis by Enhancing Peroxisome Proliferator-activated Receptor γ (PPARγ) and C/EBPα Gene Expression during the Differentiation of 3T3-L1 Preadipocytes, J. Biol. Chem., 277, 46226–46232, 2002.

Quintanilla, R., Milan, D., and Bidanel, J. P.: A further look at quantitative trait loci affecting growth and fatness in a cross between Meishan and Large White pig populations, Genet. Sel. Evol., 34, 193–210, 2002.

Rolli, V., Radosavljevc, M., Astier, V., Macquin, C., Castan-Laurell, I., Visentin, V., Guigné, C., Carpéné, C., Valet, P., Gilfillan, S., and Bahram, S.: Lipolysis is altered in MHC class I zinc-α2-glycoprotein deficient mice, FEBS Lett., 581, 394–400, 2007.

Rosen, E. D., Walkey, C. J., Puigserver, P., and Spiegelman, B. M.: Transcriptional regulation of adipogenesis, Genes. Dev., 14, 1293–1307, 2000.

Russell, S. T. and Tisdale, M. J.: Effect of a tumour-derived lipid-mobilising factor on glucose and lipid metabolism in vivo, Br. J. Cancer., 87, 580–584, 2002.

Russell, S. T., Hirai, K., and Tisdale, M. J.: Role of β3-adrenergic receptors in the action of a tumour lipid mobilizing factor, Br. J. Cancer., 86, 424–428, 2002.

Russell, S. T., Zimmerman, T. P., Domin, B. A., and Tisdale, M. J.: Induction of lipolysis in vitro and loss of body fat in vivo by zinc-α2-glycoprotein, BBA Mol. Cell. Biol. L., 1636, 59–68, 2004.

Schweiger, M., Schreiber, R., Haemmerle, G., Lass, A., Fledelius, C., Jacobsen, P., Tornqvist, H., Zechner, R., and Zimmermann, R.: Adipose Triglyceride Lipase and Hormone-sensitive Lipase Are the Major Enzymes in Adipose Tissue Triacylglycerol Catabolism, J. Biol. Chem., 281, 40236–40241, 2006.

Singla, P., Bardoloi, A., and Parkash, A. A.: Metabolic effects of obesity: A review, World J. Diabetes, 1, 76–88, 2010.

Spurlock, M. E. and Gabler, N. K.: The Development of Porcine Models of Obesity and the Metabolic Syndrome, J. Nutr., 138, 397–402, 2008.

Todorov, P. T., McDevitt, T. M., Meyer, D. J., Ueyama, H., Ohkubo, I., and Tisdale, M. J.: Purification and Characterization of a Tumor Lipid-mobilizing Factor, Cancer Res., 58, 2353–2358, 1998.

Vidal-Puig, A. J., Considine, R. V., Jimenez-Liñan, M., Werman, A., Pories, W. J., Caro, J. F., and Flier, J. S.: Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids, J. Clin. Invest., 99, 2416–2422, 1997.

Wei, W. H., Skinner, T. M., Anderson, J. A., Southwood, O. I., Plastow, G., Archibald, A. L., and Haley, C. S.: Mapping QTL in the porcine MHC region affecting fatness and growth traits in a Meishan/Large White composite population, Anim. Genet., 42, 83–85, 2011.

Wells, J. C. K.: The programming effects of early growth, Early Hum. Dev., 83, 743–748, 2007.

Wu, Z., Xie, Y., Bucher, N. L., and Farmer, S. R.: Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis, Genes. Dev. Oct., 9, 2350–2363, 1995.

Zhang, C. Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y. B., Zheng, X. X., Wheeler, M. B., Shulman, G. I., Chan, C. B., and Lowell, B. B.: Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes, Cell, 105, 745–755, 2001.