Journal cover Journal topic
Archives Animal Breeding Archiv Tierzucht
Journal topic

Journal metrics

IF value: 0.991
IF0.991
IF 5-year value: 1.217
IF 5-year
1.217
CiteScore value: 2.0
CiteScore
2.0
SNIP value: 1.055
SNIP1.055
IPP value: 1.27
IPP1.27
SJR value: 0.425
SJR0.425
Scimago H <br class='widget-line-break'>index value: 28
Scimago H
index
28
h5-index value: 13
h5-index13
Supported by
Logo Leibniz Institute for Farm Animal Biology Logo Leibniz Association
Volume 56, issue 1
Arch. Anim. Breed., 56, 1–10, 2013
https://doi.org/10.7482/0003-9438-56-001
© Author(s) 2013. This work is distributed under
the Creative Commons Attribution 3.0 License.
Arch. Anim. Breed., 56, 1–10, 2013
https://doi.org/10.7482/0003-9438-56-001
© Author(s) 2013. This work is distributed under
the Creative Commons Attribution 3.0 License.

  10 Oct 2013

10 Oct 2013

The equine DNAH3 gene: SNP discovery and exclusion of an involvement in recurrent airway obstruction (RAO) in European Warmblood horses

M. Shakhsi-Niaei1, J. Klukowska-Rötzler1, C. Drögemüller1, V. Gerber2, and T. Leeb1 M. Shakhsi-Niaei et al.
  • 1Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland
  • 2Swiss Institute of Equine Medicine, Vetsuisse Faculty, University of Bern and ALP-Haras, Bern, Switzerland

Abstract. Recurrent airway obstruction is one of the most common airway diseases affecting mature horses. Increased bronchoalveolar mucus, neutrophil accumulation in airways, and airway obstruction are the main features of this disease. Mucociliary clearance is a key component of pulmonary defense mechanisms. Cilia are the motile part of this system and a complex linear array of dynein motors is responsible for their motility by moving along the microtubules in the axonemes of cilia and flagella. We previously detected a QTL for RAO on ECA 13 in a half-sib family of European Warmblood horses. The gene encoding DNAH3 is located in the peak of the detected QTL and encodes a dynein subunit. Therefore, we analysed this gene as a positional and functional candidate gene for RAO. In a mutation analysis of all 62 exons we detected 53 new polymorphisms including 7 non-synonymous variants. We performed an association study using 38 polymorphisms in a cohort of 422 animals. However, after correction for multiple testing we did not detect a significant association of any of these polymorphisms with RAO (P>0.05). Therefore, it seems unlikely that variants at the DNAH3 gene are responsible for the RAO QTL in European Warmblood horses.

Download
Citation