Structural features of the 5’ flanking region of the Yak (Bos grunniens) growth hormone receptor (GHR) gene (Brief Report)

Abstract. Yak (Bos grunniens) is a species of the Bovidae family living on the Qinghai-Tibetan Plateau and its adjacent territories at altitudes from 2 000–5 000 m (LUO et al. 2005, MA et al. 2009). As a multi-purpose domestic animal, yaks are indispensable to the local animal husbandry development because it can provide life necessities such as meat, milk, fur, velour manufacturing, transportation and manure for fuel to the local herdsmen. There are twelve yak populations numbered around 13.3 million in China and the Bazhou yak is one of Chinese yak populations (WIENER et al. 2003). The Growth Hormone Receptor (GHR) gene was identified as a candidate gene affecting key quantitative traits, like growth, milk yield and composition in livestock. At present, only investigations were carried out on the genetic variation in Exon-8, Intron-8 and Exon-10 of the yak GHR gene (VARVIO et al. 2008), no other information on the yak GHR gene is available. The purposes of this study were to

– analyze the structural features of the 5’ flanking region of the yak GHR gene
– compare the 5’ flanking region of yak GHR gene with that of other species of the Bovidae family and
– construct the phylogenetic tree to indicate the evolutionary relationship among them.