Levels of serum osteocalcin and some electrolytes in foal during the first six months of life (Brief Report)

Abstract. Bone is a dynamic tissue characterized by continuous bone formation and bone resorption. The transformation of the primordial part of the long bones (the cartilaginous matrix during the embryonal period) into the definitive bone (lamellar bone tissue) is completed after puberty. Osteocalcin, also called the vitamin k-dependent protein of bone and synthesized predominantly by osteoblasts and in lower way by odontoblasts, is incorporated into the extracellular matrix of bone (LEPAGE et al. 2001) and it may function as a useful indicator of the equine bone growth rate which decreases considerably with age. In particular, osteocalcin or bone Gla-protein is a small abundant non-collagenous calcium binding protein, indigenous to the organic matrix of bone dentin and possibly other mineralized tissue, which circulates in the blood (LEPAGE et al. 1991). It is accepted as a marker of osteoblast activity (RISTELI and RISTELI 1993) and plays a not yet defined role in the regulation of bone turnover (BOSKEY et al. 1998).