Articles | Volume 52, issue 3
https://doi.org/10.5194/aab-52-284-2009
https://doi.org/10.5194/aab-52-284-2009
10 Oct 2009
 | 10 Oct 2009

Vergleichende Untersuchungen zu ausgewählten Kriterien des Energiestoffwechsels in Skelettmuskulatur, Plasma und Lymphozyten bei gesunden und an Congenitaler Myofibrillärer Hypoplasie erkrankten Ferkeln

A. Bull, P. Engel, and V. Dzapo

Abstract. Title of the paper: Comparative investigations of selected criteria of energy metabolism in skeletal muscle, plasma and lymphocytes in healthy and in piglets with congenital myofibrillar hypoplasia
Carnitine contents of skeletal muscle, plasma and lymphocytes, the capacity of ATPsynthesis in muscle mitochondria and lymphocytes, and the enzyme activity of carnitine palmitoyltransferase I (CPT I) in muscle mitochondria were determined in piglets with congenital myofibrillar hypoplasia (CMH) in comparision to their clinical healthy siblings and piglets from CMH-free litters. Tendentious differences in the relation of acylcarnitine to free carnitine in healthy piglets and piglets suffering from CMH could be detected. Healthy piglets showed in tendency superiority in the ATP-production of their lymphocytes compared with diseased animals. Depending on the applied substrate, muscle mitochondria showed tendentially differences in the ATP-production between CMH-affected and healthy litters, so that a connection between CMH and the lipid metabolism, particular the β-oxidation, is supposed. Differences in the carnitine palmitoyltransferase I-activity as a possible cause for CMH could be excluded.