Phylogenic analysis of the SLA-1 gene variants observed from Korean Jeju pig (Brief Report)
Abstract. The Swine Leukocyte Antigen (SLA) class I consists of SLA-1, SLA-2, and SLA-3 genes (CHARON et al., 2000) that are expressed on the surface of most nucleated cells. Pig organs mainly from miniature pigs have been used in studies on xenotransplantation (SMITH et al., 2005). It is important to understand genetic variations of the SLA-1 gene considering the SLA-mediated immune responses. Collecting information on single nucleotide polymorphisms (SNPs) and alleles of SLA-1 and their phylogenic relationships is important regarding future uses of the Korean Jeju Pig (KJP) in xenotransplantation.