Phylogenic analysis of the SLA-1 gene variants observed from Korean Jeju pig (Brief Report)

Chung, H.; Yoon, S.; Beck, M.; Park, H.; Kim, J.

doi:https://doi.org/10.5194/aab-50-628-2007

Articles | Volume 50, issue 6

https://doi.org/10.5194/aab-50-628-2007

© Author(s) 2007. This work is distributed under
the Creative Commons Attribution 3.0 License.

https://doi.org/10.5194/aab-50-628-2007

© Author(s) 2007. This work is distributed under
the Creative Commons Attribution 3.0 License.

Articles | Volume 50, issue 6

10 Oct 2007

| 10 Oct 2007

Phylogenic analysis of the SLA-1 gene variants observed from Korean Jeju pig (Brief Report)

H. Chung, S. Yoon, M. Beck, H. Park, and J. Kim

Abstract. The Swine Leukocyte Antigen (SLA) class I consists of SLA-1, SLA-2, and SLA-3 genes (CHARON et al., 2000) that are expressed on the surface of most nucleated cells. Pig organs mainly from miniature pigs have been used in studies on xenotransplantation (SMITH et al., 2005). It is important to understand genetic variations of the SLA-1 gene considering the SLA-mediated immune responses. Collecting information on single nucleotide polymorphisms (SNPs) and alleles of SLA-1 and their phylogenic relationships is important regarding future uses of the Korean Jeju Pig (KJP) in xenotransplantation.