10 Oct 2007
10 Oct 2007
Five novel single nucleotide polymorphisms (SNPs) of the prophet of PIT1 (PROP1) gene in bovine (Brief report)
C. Pan1, X. Lan1,2, H. Chen1,3, L. Hua1, Y. Guo1, B. Zhang1, and C. Lei1
C. Pan et al.
C. Pan1, X. Lan1,2, H. Chen1,3, L. Hua1, Y. Guo1, B. Zhang1, and C. Lei1
- 1College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China
- 2Institute of Biochemistry, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China
- 3Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China
- 1College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China
- 2Institute of Biochemistry, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China
- 3Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China
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Abstract. The prophet of Pit1 (PROP1) gene encodes a paired class homeodomain transcription factor of 226 amino acids and is organized of 3 exons. PROP1 is necessary for the specification, differentiation and proliferation of cells. Its function is essential for anterior pituitary organogenesis, and heritable mutations in this gene are associated with combined pituitary hormone deficiency (CPHD) in human patients and animals (SAVAGE et al., 2003; CARVALHO et al., 2006). To date, no polymorphisms of the bovine PROP1 gene were described. In the present experiment, the 5' flanking region, the coding region and partial introns of bovine PROP1 were scanned for single nucleotide polymorphism (SNPs) in five cattle breeds of China.
