Articles | Volume 50, issue 2
10 Oct 2007
 | 10 Oct 2007

Eleven single nucleotide polymorphisms (SNPs) were found at coding region of hypocretin receptor1 (HCRTR1) gene in cattle (Brief report)

L. Zhang, A. L. Zhang, H. Chen, C. L. Zhang, L. Z. Zhang, Z. Y. Zhu, C. Z. Lei, X. Y. Lan, and X. Z. Wang

Abstract. The hypocretin receptor1 (HCRTR1) gene encodes a Orexin A receptor (SAKURAI et al., 1998). It belongs to the class Ι subfamily within the superfamily of G-coupled receptors and is coupled to Ca2+ mobilization. Via HCRTR1, Orexin A is involved in the control of feeding, sleep-wakefulness, neuroendocrine homeostasis and autonomic regulation (VOISIN et al., 2003; TAKESHI SAKURAI, 1999). These characters are important in animal production. In human, a 408 isoleucine to valine mutation in HCRTR1 showed significant association with polydipsic–hyponatremic schizophrenia (MEERABUX et al., 2005). By now, no polymorphisms of the bovine HCRTR1 gene were reported.