Articles | Volume 50, issue 1
10 Oct 2007
 | 10 Oct 2007

Assignment of solute carrier family 2 (facilitated glucose transporter), members SLC2A2, SLC2A3, SLC2A5, SLC2A8 and SLC2A12 to porcine chromosomes by somatic cell and radiation hybrid panel mapping (Brief report)

K. Liu, S. Zhao, B. Liu, B. Fan, C. Li, and M. Yu

Abstract. The transport of glucose plays an important role in cellular glucose homeostasis and metabolism [1]. Due to the hydrophilic character of glucose, the transport of glucose in and out of cells requires specific carrier proteins. The mammalian facilitative glucose transport family, which contains the energy-independent transporters (gene symbol SLC2A, protein symbol GLUT), catalyzes the entry of glucose into mammalian cells by facilitative diffusion down a concentration gradient. Thirteen members of mammalian GLUT family have been now characterized [1]. In swine, the chromosomal locations for the five genes (SLC2A2, SLC2A3, SLC2A5, SLC2A8 and SLC2A12) have not yet been determined. In this study, as the first step to better understand of the roles of these GLUTs in pigs which could subsequently be beneficial for pig production, we report the mapping of the five genes using both porcine somatic cell hybrid panel (INRA-SCHP) and radiation hybrid panel (IMpRH).