Mapping of CARD4 gene to pig chromosome 18 (Brief report) (Kartierung des CARD4 Gens auf dem Schweinechromosom Nr. 18)

Abstract. The caspase recruitment domain family, member 4 gene (CARD4) is a member of the CATERPILLER (caspase recruitment domain, transcription enhancer, r (purine)-binding, pyrin, lots of leucine repeats) family. In humans, CARD4 has been shown to be involved in the innate immune system responsible for cytosolic recognition of bacteria. This gene also contributes to the inflammation processes seen in asthma (HYSI et al., 2005) and intestinal bacterial infections (KIM et al., 2004). The human CARD4 gene is located on chromosome 7. It contains 14 exons and spans approximately 4.4 kb. The objective of this study was to determine the chromosomal location of CARD4 in the pig by linkage and RH mapping.