The hypothalamic hormone, growth hormone-releasing hormone (GHRH), is the principal stimulator of pituitary growth hormone (GH) synthesis and secretion. Its pituitary receptor is well characterized as a member of the superfamily of G protein-coupled receptors (MAYO et al., 1992). GHRH and its receptor provide important functions in the regulation of the GH axis and in the development and proliferation of pituitary somatotropes (LIN-SU et al., 2002). By now, polymorphisms of bovine <i>GHRHR</i> were not reported. In the present experiment the 5' flanking region, the coding region and partially introns of <i>GHRHR</i> were screened to detect the SNPs in the predominant cattle breeds of China.