AAB Archives Animal Breeding AAB Arch. Anim. Breed. 2363-9822 FBN Dummerstorf Göttingen, Germany 10.5194/aab-50-322-2007 Assignment of the <i>TYK2</i> gene to equine chromosome 7q12-q13 (Brief report) Stübs D. 1 Kuiper H. 1 Mömke S. 1 Chowdhary B. P. 2 Distl O. 1 Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Germany Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A&M University, College Station, TX-77843, USA 10 10 2007 50 3 322 323 Copyright: © 2007 D. Stübs et al. 2007 This work is licensed under the Creative Commons Attribution 3.0 Unported License. To view a copy of this licence, visit https://creativecommons.org/licenses/by/3.0/ This article is available from https://aab.copernicus.org/articles/50/322/2007/aab-50-322-2007.html The full text article is available as a PDF file from https://aab.copernicus.org/articles/50/322/2007/aab-50-322-2007.pdf

Tyrosine kinase 2 (<i>TYK2</i>) is a member of the janus kinase gene family and encodes an 1187 amino acid protein. All four members of the janus kinase family <i>JAK1</i>, <i>JAK2</i>, <i>JAK3</i>, and <i>TYK2</i> associate with various cytokine receptors and mediate the signal transduction by tyrosine phosphorylation of downstream targets (YAMOAKA et al., 2004). Studies with <i>tyk2</i> deficient mice demonstrated impairment of interferon α/β signaling (KARAGHIOSOFF et al., 2003). Mutations in the murine <i>tyk2</i> gene are associated with increased susceptibility to infectious and autoimmune diseases (SHAW et al., 2003). The human <i>TYK2</i> gene consists of 25 exons spanning 30,003 bp on human chromosome 19p13.2 starting at 10,322,209 bp. The objective of this study was to determine the chromosomal location of <i>TYK2</i> in the horse by FISH and RH mapping.